Record whether pre-existing crystals participate before assigning a nucleation event to a primary or secondary route.
Define the Phase or Process Boundary
METTLER TOLEDO's crystallization mechanism definitions distinguishes primary nucleation from secondary nucleation associated with existing solids. Seed presence is important context, but a final increase in particle count alone does not prove the secondary mechanism.
Review a Hypothetical Comparison
Imagine an invented seeded trial that begins with 100 characterized crystals and ends with 160 counted objects. Before naming 60 secondary nuclei, ask whether the original seeds broke, agglomerates dispersed, uncounted objects entered the sampled field or a primary event also occurred. A matched initially seed-free comparison and time-resolved seed history can help address the causal question; neither comparison substitutes for controlling the actual solution state.
Keep the Evidence with the Decision
Keep the initial seed population and preparation history visible. Review the order of events: existing-crystal interaction, appearance of new objects and any mechanical fragmentation. Name the evidence that links existing crystals to the new population rather than using seeded as a synonym for exclusively secondary. Preserve a mixed or unresolved interpretation when the observation cannot separate routes.
This is a fictional review scenario, not a nucleation experiment or seed-loading recommendation. It sets no cooling, mixing or supersaturation limit.
What evidence separates nucleation without pre-existing crystals from crystal-dependent generation?
This blank worksheet is for your own project. It contains no H M machine trial result.
| Review field | Reference or result | Responsible person |
|---|---|---|
| Initial seed inventory and state | To complete | To complete |
| Time order of crystal interactions and births | To complete | To complete |
| Possible fragmentation or sampling changes | To complete | To complete |
| Matched seed-free comparison and unresolved routes | To complete | To complete |
Customer Questions
Does seed presence rule out primary nucleation?
No. The event evidence must distinguish routes.
Is every new object a new nucleus?
Fragmentation and observation-boundary changes can also increase count.
Does this set the required seed loading?
No. That needs evidence for the actual crystallization system.
Primary References
These references support the technical principles discussed in this guide. The worked examples and review questions are educational.
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